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Bacterial infections are a major threat in medicine, often causing significant morbidity and mortality. Despite the effectiveness of antibiotics, the rise of antibiotic-resistant strains presents a pressing challenge worsened by misuse. Antibiotics target essential cellular processes to combat microorganisms, including bacteria, fungi, and viruses. Nanoparticles offer promising alternatives with customizable properties for targeted therapy, employing unique antibacterial mechanisms. Carbon-based, metal-based, polymeric, and lipid-core nanocapsules show potential in inhibiting bacterial growth and curbing resistance. Lipid-core nanocapsules are versatile platforms for drug delivery, enhancing antibacterial activity and altering interactions with bacterial cells. In this study, we explore the efficacy of lipid-core nanocapsules in combating antibiotic resistance and improving patient outcomes, paving the way for advancements in modern medicine.